| abstract |
The present invention relates to a human growth hormone fusion protein, consisting of the amino acid sequence of SEQ ID NO: 3 or SEQ ID NO: 4, with increased thermal stability, a human growth hormone fusion protein encoding gene, optimized for E. coli codons, consisting of the nucleotide sequence of SEQ ID NO: 5 or SEQ ID NO: 6, a recombinant vector carrying the gene, a host cell transformed with the recombinant vector, a method for producing a human growth hormone fusion protein by transforming the recombinant vector into a host cell, and a cosmetic composition containing as an effective ingredient a human growth hormone fusion protein increased in thermal stability for improving skin wrinkles and maintaining skin elasticity. Having thermal stability and the effect of improving skin wrinkles and maintaining skin elasticity, the cosmetic composition of the present invention can be usefully used as a functional cosmetic raw material. |