| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_459549086df37b5bed0003502de7e7aa |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65616 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6561 |
| filingDate |
2017-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff5429af211fcd0c14dc545b11a430bf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_932f87969b854dfe23d178461898185e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_710256ba1d4dd187fb3448fcf0bd5e8d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3619cb6afc169602217765776e3c9bd5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_365553a15948a4325817adef149de728 |
| publicationDate |
2017-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2017118928-A1 |
| titleOfInvention |
Process for the separation of diastereomers of tenofovir alafenamide |
| abstract |
The invention describes a process and diastereomeric salts useful for the optical resolution of 9-[(R)-2-[[(R,S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]-phenoxyphosphinyl] methoxy] propyl] adenine and intermediates thereof. The process comprises placing into solution a chiral resolving agent, either L/D-Proline or L/D-Phenylalanine, precipitating the resulting diastereomeric salt between the chiral resolving agent and the target enantiomer and separating the enantiomer. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111189947-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110283208-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111189947-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114804989-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110283208-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107522743-A |
| priorityDate |
2016-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |