| abstract |
The present invention relates to an Mfge8 fusion protein comprising a (poly)peptide of interest covalently bound by a linker to an Mfge8 protein, wherein the Mfge8 fusion protein has a phosphatidylserine (PS)-binding activity and, optionally, an RGD-binding activity. The invention further relates to a composition comprising the Mfge8 fusion protein of the invention, as well as to the Mfge8 fusion protein of the invention or the composition comprising same for use in medicine, in particular for use in the treatment of cancer and for use in the diagnosis or treatment of a disease associated with cell death or with a defect in phagocytosis. Furthermore, the present invention relates to a method of detecting cell death, to a method of analyzing phagocytosis of dying cells, to a method of diagnosing a disease associated with a defect in phagocytosis, and to a method of determining the effectiveness of a therapeutic treatment of cancer or myocardial infarction. |