http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017113428-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_abd1720010f18941d443ec59d03892eb http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1e74277852f1aae0a3ff13f59a65456d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00 |
| filingDate | 2016-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a87d53019d495050878fdd36f80a2fd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b0d83183d0aa640c92b3d9820b0d74b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_690d89f96661354072ac220f16d7cadd |
| publicationDate | 2017-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2017113428-A1 |
| titleOfInvention | Preparation of unnatural cyanoamino acids and application thereof in bioorthogonal raman detection |
| abstract | Disclosed are a method for synthesizing a number of aliphatic cyanoamino acids and application of the cyanoamino acids in bioorthogonal Raman detection. The aliphatic cyanoamino acids are methionine derivatives and lysine derivatives. The method comprises reacting a compound having a structural formula (I) with POCl 3 n dissolved in pyridine to obtain the cyanoamino acids. The provided method for synthesizing cyanoamino acids is mainly suitable for aliphatic cyanoamino acids, such as cyanoamino acids containing amido linkage and carbonate ester linkage. With a partially protected precursor amino acid as a backbone, the reaction involves dehydration of the precursor amino acid and formation of amido linkage or carbonate ester linkage to introduce cyano groups onto the amino acid backbone, followed by deprotection wherein the cyano groups are prevented from being hydrolyzed. The synthesis process involves fewer operations at high or low temperatures and needs less energy. The end products are purified with hydrophilic interaction chromatography (HILIC) to obtain cyanoamino acids of ultrahigh purity. The cyanoamino acids can be incorporated into proteins by means of gene codon amplification technique and be used in bioorthogonal Raman detection. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110845365-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110845365-A |
| priorityDate | 2015-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.