http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017109046-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a5f3156aa0ad3cc45897ab49cebd19ea |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-32 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-32 |
| filingDate | 2016-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75e87fb71f19ec3051dc38c3e2452e1e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9762afcb5a45f57be11ac7d0295dc12f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4bbd7af41990df85cd13249b10086bff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_28f00434c7796becc68e61b16826f48e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fff35f22c6f1ec5fe38a827e6a351bea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_707558b9a8897d3c736307e28610822d |
| publicationDate | 2017-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2017109046-A1 |
| titleOfInvention | Enzymatic method for the evaluation of xylose |
| abstract | The invention provides an alternative sensitive and specific method for D-xylose quantification that could replace the colorimetric method without compromising detection accuracy, using xylose dehydrogenase, particularly XylB from Caulobacter crescentus NA-1000, as the only enzyme in the assay kit. This enzymatic method can be used to quantify D-xylose in urine and/or blood samples after performing a test to diagnose hypolactasia. This test is non-invasive and involves the ingestion of the disaccharide 4-O-beta-galactopyranosyl-D-xylose (4-GX or Gaxilose). This disaccharide is hydrolysed by intestinal lactase, producing D-xylose, which is absorbed into the blood and excreted in urine. D-Xylose levels in urine and blood are proportional to the quantity of intestinal lactase. Thus, the test provides an evaluation of the global intestinal lactase activity in the whole individual and it is not based on measuring the metabolic consequences derived from its deficiency. It does not require specialised equipment, does not cause apparent discomfort in patients with lactase deficiency and is very reliable, thus overcoming the drawbacks of the diagnostic tests currently in use. Moreover, the enzymatic method for D-xylose detection of invention is statistically significantly better than the xylose quantification colorimetric methods in terms of its reliability. This could allow the diagnostic test to become the reference or gold standard test for the indication of hypolactasia diagnosis. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019217226-A1 |
| priorityDate | 2015-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 509.