| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a7ebd2ce5ef7e691bd44c48a88a2bfc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a07a532023c53ebaab0e22ec3d595ac8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3a9adf994ff8430c3ff277347330d79c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dcad96abf486695c4ab9036b1c2a8ca8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_77706347f015c6796566e07658b1413e |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-118
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-154 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6809
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6841 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2016-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e9055f7942c5ffb79f63c5eb5b980dc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5286fb65cabb4244c718caadd651a320
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36db8fdf2e111e5e6f39c8b7065d0211
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a06cc339e6bb47f4454bf932fc4d666 |
| publicationDate |
2017-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2017106290-A1 |
| titleOfInvention |
Methods of detecting insulator dysfunction and oncogene activation for screening, diagnosis and treatment of patients in need thereof |
| abstract |
The present application generally to the diagnosis and treatment of diseases resulting from the alteration of chromatin boundaries between topologically-associated domains. In particular, the present application relates to detection of mutations causing DNA hvpermethylation phenotypes, CpG methylation within CTCF binding motifs, and aberrant gene expression caused by altered chromatin topology. Applicants show that IDH mutant gliomas exhibit hyper-methyiation at CTCF binding sites, compromising binding of this methylation- sensitive insulator protein. Applicants also demonstrate that loss of CTCF at a domain boundary permits a constitutive enhancer to aberrantly interact with the receptor tyrosine kinase gene PDGFRA, a prominent glioma oncogene. Thus, Applicants have uncovered that IDH mutations may promote gliomagenesis by disrupting chromosomal topology and allowing aberrant regulatory interactions that induce oncogene expression. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3510152-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3867368-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108647492-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108647492-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11560597-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111190364-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11624065-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11312955-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10662425-B2 |
| priorityDate |
2015-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |