| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_47103a331b74b79cd345917d99f0a456
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9791dc672011e65a541164694b6156a2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_894519bc4078ed0bdecea065e13153f1 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-91097
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2405-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-50 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-3084
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57415
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-573
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5073 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 |
| filingDate |
2016-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d538fce85d40ce70d6956c681edb810e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eaaca45685e500619c1738bd3c18954b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55c719b1e48e0792a121846135565353
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bca9893ce3402cf419213dbe93db117c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_11a1efc1e9ef826d0787473a6a3b59ac |
| publicationDate |
2017-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2017100796-A1 |
| titleOfInvention |
Modulation of globoseries glycosphingolipid synthesis and cancer biomarkers |
| abstract |
The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta- 4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions. Furthermore, the instant disclosure also relates to cancer stem cell biomarkers for disgnostic and therapeutic uses. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113209302-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113209302-B |
| priorityDate |
2015-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |