| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_22f5540afcbd154be7183e8e18a69765 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-28 |
| filingDate |
2016-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f32d5895c1f46cad2b4b055c2e62631
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_392ea01639c85b413574816dd6a541bf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dcfaf62607c4f4e7b8550dc2630b7c6d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec85683758e990ad5afb3f79820776fe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e3ee4d24c174cca3045dd3dc2ee6e7a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_417bee55a995a4a6cfae0dcd87f6b293 |
| publicationDate |
2017-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2017099637-A2 |
| titleOfInvention |
Method for isolating polysialized human insulin |
| abstract |
The invention relates to medicine and concerns a method for isolating a protein containing insulin and one polysialic acid residue from reaction byproducts and unreacted starting material, by means of reverse-phase chromatography. The method employs the chromatographic material PLRP-S equilibrated with a solution comprising a non-polar component in an amount of 2-8%, and a stepwise gradient elution. The invention provides for a high-purity protein in one isolation step. |
| priorityDate |
2015-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |