| abstract |
The present invention is directed to the compounds of Formula (I) or isomers, stereoisomers, tautomers, pharmaceutically acceptable salts, isotopes, solvates, metabolites, polymorphs or prodrugs thereof, wherein R1, R2, R3, R4, /A, B, L1, L2, Z, n and X are herein defined as inhibitors of PI3K. These compounds are used for the preventive and/or therapeutic treatment of diseases or disorders associated with abnormal activities of PI3K's such as Inflammation, Cancer, Restenosis, Atherosclerosis, Psoriasis, Thrombosis, immmuno-oncology, renal carcinoma, hepatitis C, haematological malignancies, and multiple myeloma. |