| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3d7e2f8fb5650d7d3616661464b67771 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-004 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6558
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65583
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-675 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6558
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-675
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
2016-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7709a21d26dc4e6edf3c675d5acde73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b3a2c32e324f645c68e53c76daba203
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8faac3462bfde6431fba74b8ad14b0ed |
| publicationDate |
2017-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2017088784-A1 |
| titleOfInvention |
Deuterium-modified brigatinib derivatives, pharmaceutical compositions comprising same, and use thereof |
| abstract |
The present invention belongs to the field of pharmaceutical chemistry, and relates to deuterium-modified Brigatinib derivatives, preparation methods thereof, pharmaceutical compositions comprising deuterium-modified Brigatinib derivatives, and a use of the deuterium-modified Brigatinib derivatives and the pharmaceutical compositions comprising the same in the preparation of medicaments for treating diseases mediated by anaplastic lymphoma kinases. The deuterium-modified Brigatinib derivatives of the present invention exhibit an excellent inhibitory activity against anaplastic lymphoma kinases, and have better pharmacodynamic or pharmacokinetic properties compared to Brigatinib. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113024454-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109593102-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020184670-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2020385527-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112824420-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20210139317-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109593102-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019134573-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109851638-A |
| priorityDate |
2015-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |