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filingDate 2015-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d254e88060b89d899723a92a5d9c586a
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publicationDate 2017-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2017084064-A1
titleOfInvention Use of electronic olfactory device in on-line detection of cyclohexanecarboxylic acid concentration during dolomycin fermentation
abstract Provided is a use of an electronic olfactory device in on-line detection of a cyclohexanecarboxylic acid concentration during dolomycin fermentation. An optimization method for supplementing a precursor during the dolomycin fermentation is determined. Namely, the cyclohexanecarboxylic acid in the fermentation broth is maintained at the optimum concentration by means of on-line detection and feedback of the supplementary addition amount of the precursor substance of cyclohexanecarboxylic acid using the electronic olfactory device, not only satisfying the amount of the precursor required for the bacterial synthesis of doramectin, but also not adversely affecting the metabolic activity of the bacteria. This method makes up for the shortcomings where sampling during the process to perform liquid chromatography or gas chromatography is time-consuming and where it is difficult to achieve on-line detection and timely control.
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