| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d7296d758d68ba2a6d6139262eb6587f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5b53bbae9686bcca0d26775dde24d67c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_55a97b3da8db6f76d88e74f8233fcdc6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8b6fd30537f74ade6990f8182a80c789
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e9d041a9ea2d6f30e9d3894b8b7ad3f6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b874595bcf02dd3677f0d23e290ad9b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9961f2c8e3fdf32fe01073d3429997e6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_995580f8aa5352b394be6e5fae1fb7b1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1af810e7a75c5bfe6754e84b506fd46f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27cb0bdfe70704698e91a2c9cc6238e3 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5154
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-572
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-57
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55572
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55555
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55522
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-585
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-20034 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0639
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00117
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K17-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0784
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00 |
| filingDate |
2016-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37b2116546f650a526fd5bc3af593534
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a97a364bfd2568160422f555e6ee4d7e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a300a226051196c40ab4c46b1ab59361
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_525848efb2e5044992da86e05d1a323c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4027f5a35031211437ea49514ae2eb22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a46df1db8a401602c2d06231b4b64fcd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b43df2a410bfdcd93d6ec64a65a2bd7a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8987abb2b8276ecb26da3f9c36ae4b8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aca9d76bc37e7283dc44500e1bd52b54 |
| publicationDate |
2017-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2017083820-A1 |
| titleOfInvention |
Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy |
| abstract |
The invention covers the use of certain classes of lipids including cationic lipids in ex-vivo dendritic cell therapies. The cationic lipids enhance antigen uptake, processing and presentation of the processed antigens by dendritic cells to CD8+ and CD4+ T-cells via the MHC classes I and II presentation pathways respectively. Antigen uptake via cationic lipid by dendritic cells result in significant lowering of the population of the immune suppressive regulatory T cells in the tumors and a significant increase of the tumor targeting cytotoxic T-cells. Loss of regulatory T cells and increase of tumor specific cytotoxic cells are conducive to effective elimination of the tumors. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11638753-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11612652-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3720423-A4 |
| priorityDate |
2015-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |