| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7313a468c156d1904c632f9d188c3584 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-09 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C43-23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C41-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-08 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C43-225 |
| filingDate |
2016-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32660f79f4e9d2b3e39e7cf164512fbe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b47091ab34962d0d098b38c8e1e90511
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1418580b51c84852435ea922958ef34 |
| publicationDate |
2017-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2017080770-A1 |
| titleOfInvention |
Synthesis of (z)-endoxifen hydrochloride |
| abstract |
The invention relates to the synthesis of tamoxifen, endoxifen and derivatives thereof. Starting from a substituted benzoic acid derivative and 2-phenoxyethyl halide, the intermediate product of general formula (I) is obtained. The compound of general formula (VI) or a salt thereof is obtained from the compound of general formula (I), via isomer purification of the compound of general formula (I) by obtaining the (Z)-isomers and reacting the (Z)-isomers with an amine of formula HNR 6 R 7 . Alternatively, the compound of general formula (I) is reacted with a compound of formula HNR 6 R 7 , and the amine thus obtained is then subjected to isomer purification, wherein the compound of general formula (VI) or a salt thereof is obtained. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3365322-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111328280-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11680036-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11572334-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11261151-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2020533283-A |
| priorityDate |
2015-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |