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filingDate 2016-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46a7b74b256a0bb76bdf9ba97d10c344
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publicationDate 2017-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2017079830-A1
titleOfInvention Methods for synthesizing peptide-tagged pegylated chitosan
abstract Provided are synthetic schemes for the synthesis of a derivatized chitosan polymer, grafted with polyethylene glycol (PEG) and a peptide such as a cell-targeting/cell penetrating peptide. In alternative embodiments, provided are synthetic schemes for the preparation of a peptide tagged PEGylated phthaloyl chitosan (CS-O-PEG-peptide), or a CS-O-PEG- TAT if the peptide is a TAT. Provided are synthetic schemes for the preparation of a PEGylated Phthaloyl Chitosan (CS-PH-O-PEG-peptide), or a CS-PH-O-PEG-TAT if the peptide is a TAT. In alternative embodiments, provided are protocols and synthetic schemes for the preparation of a phthaloyl chitosan and a homo-bifunctional di-carboxylic acid polyethylene glycol (COOH-PEG-COOH). Provided are protocols and synthetic schemes for the preparation of a peptide tagged PEGylated chitosan (CS-O-PEG- peptide). Provided are peptide-tagged PEGylated chitosan (CS-O-PEG-peptide) (optionally CS-O-PEG-TAT if the peptide is a TAT) made by a method or synthetic scheme as provided herein.
priorityDate 2015-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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