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publicationDate 2017-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2017074500-A1
titleOfInvention Systems and methods for cross-linking treatments of an eye
abstract A corneal treatment system includes an illumination system configured to deliver photoactivating light to a cross-linking agent applied to a cornea. The system includes a controller that receives input relating to a desired biomechanical change in the cornea and executes program instructions to: (i) determine, from a photochemical kinetic model, a three- dimensional distribution of cross-links for the cornea to achieve the desired biomechanical change in the cornea, where the photochemical kinetic model calculates the distribution of cross-links based on cross-linking from (A) reactions involving reactive oxygen species (ROS) including at least peroxides, superoxides, and hydroxyl radicals, and (B) reactions not involving oxygen; and (ii) determine at least one set of treatment parameters to achieve the distribution of cross-links. The at least one set of treatment parameters includes illumination parameters for the delivery of the photoactivating light. The illumination system delivers the photoactivating light according to the illumination parameters.
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