http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017067497-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c16ad253b26d47cd551ec9e72d703b0d |
| filingDate | 2016-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1b5a1125246d7eb967c02c883b56b9f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_100e2663253ea0aa7a2394feede1bcb0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de20479e0fd69a40869c2df6caca8048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2da76f03565efb8a34fcea90f092e260 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25bc4190bed4ac1e74da6e94bd54ee51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bde4ddd19fd03c98b718f36a3da3829f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f189d70dc8b3426df56d91abe55409e |
| publicationDate | 2017-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2017067497-A2 |
| titleOfInvention | Monosubstituted or polysubstituted amphiphilic hypocrellin derivative, preparation method therefor, and uses thereof |
| abstract | Disclosed are a monosubstituted or polysubstituted amphiphilic hypocrellin derivative, preparation method therefor, and uses thereof. In the present invention, the amphiphilic hypocrellin derivative having substituted functional groups such as condensed ethylene glycol and quaternary ammonium salt shows in its absorption spectrum a substantial redshift and an enhanced molar extinction coefficient compared to hypocrellin precursor, and can highly effectively produce reactive oxygen species such as singlet state oxygen under light-sensitive conditions. By adjusting the hydrophobicity and hydrophilicity of said derivative, said derivative can have different amphiphilicity and enhanced biocompatibility with cells or tissues. The amphiphilic hypocrellin derivative can satisfy the requirements for different clinical medications and addresses the conflict between medicinal hydrophilicity and lipophilicity caused by different administration methods. Compared to the first and second generation commercial photosensitizer, under the same conditions, the amphiphilic hypocrellin derivative photosensitizer of the present invention has higher photodynamic capabilities in the eradication of live tumor cells. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109456210-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114644607-A |
| priorityDate | 2015-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 179.