| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e9e0b17a7397b2f1b810b713a0e7651 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06052
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-448
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6803 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-788
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-792 |
| filingDate |
2016-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac2769cf6e46d5ff6299e581fcc74a6b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d60a6916f7af5be77a839ba189c0bff2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05aca8cd9541c0e2d454e9391c4543e2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a43479a1a70d8e9b4775e33587c26a8 |
| publicationDate |
2017-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2017066668-A1 |
| titleOfInvention |
Drug-linker conjugate pharmaceutical compositions |
| abstract |
Compositions are disclosed having a cytotoxic and/or vascular disrupting agent (VDA) payload attached to a linker. The linker can be a cathepsin B protease cleavable linker or a non-cleavable linker that may degrade intracellularly. Methods for making and using the compositions are also provided. The compositions can be provided to a patient in need thereof with the composition coming into contact with a cancer cell to activate or release the cytotoxic and/or vascular disrupting agent payload. |
| priorityDate |
2015-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |