| abstract |
Lipoplex formulations and uses thereof. In particular, the lipoplexes include at least one naturally-occurring cationic amphiphile, at least one C18-30 saturated fatty acid, cholesterol, at least one nucleic acid, and have a low charge ratio. The lipoplexes are useful for in vivo or in vitro delivery of one or more agents (e.g., a polyanionic therapeutic or an antisense therapeutic, such as an RNAi agent) and allow prolonged expression of these agents, which may be distributed via endogenous cellular pathways to surrounding cells or tissue. |