| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7e0853d84010a31b6b07ea02c89e5415 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21076 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-482
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6424 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-48 |
| filingDate |
2016-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59ec0feb0ada9b4ad6fe223a2b9d24e0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bc8fc611e2e3281a1c8160b41977221 |
| publicationDate |
2017-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2017059548-A1 |
| titleOfInvention |
Regulation of cell to cell connections |
| abstract |
Methods and compositions for disrupting or degrading a cell-to-cell junctions using a PR3 agonist or analogue. Methods and compositions for protecting permeability across an endothelial or epithelial barrier, including protecting a blood barrier (BB) from degradation using a proteinase-3 (PR-3) antagonist. PR3 is used as a biomarker of disease/injury severity. Labelling of PR3 is used in vivo to anatomically identify sites of cell-to-cell junctional breakdown, and used to aid determination of disease resolution and/or response to therapy. |
| priorityDate |
2015-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |