| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ffb067b4d0ab903187696d90fc65b6b8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3050e279f053db7cd4fd20af0f7240ba |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70578
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-102
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-65
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4747 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-65 |
| filingDate |
2016-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0eb22c7cdb7b29d8dbccca05d29d0f75
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea8f3c7d60be9bd3657e9fdedd210838
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0ddca93b680e7f43b60b039ff02957f |
| publicationDate |
2017-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2017051000-A1 |
| titleOfInvention |
Death receptor based selection marker |
| abstract |
The present invention discloses the use of a dominant negative mutant death receptor as a selection marker for cell transfection. The invention provides new genetic constructs for the introduction and expression of heterologous genetic sequences in target host cells. The use of a dominant negative mutant death receptor as selection marker to select for positive transfectants allows for an enrichment of transfected cells and thereby significantly enhances efficiency of the transfection protocols of the herein disclosed invention. The inventive selection marker is preferably applied in genome editing approaches such as clustered, regularly interspaced, short palindromic repeat (CRISPR) mediated genome manipulation. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022167798-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021205175-A1 |
| priorityDate |
2015-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |