http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017049327-A2

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filingDate 2016-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96f4a75009b6cdd52119a17afbe513b2
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publicationDate 2017-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2017049327-A2
titleOfInvention In vivo priming of natural killer cells
abstract The disclosure concerns a method for cancer treatment by in vivo priming and activation of natural killer cells for achieving tumor cell lysis. The method includes introducing into a patient a priming tumor cell preparation (PTCP) derived from a first tumor cell line, which is irradiated to inactivate the first tumor cells or a membrane preparation thereof, the first tumor cells having known priming ligands on the membrane surface thereof. The patient's rest NK cells are contacted by the PTCP in vivo, resulting in primed NK cells, which are characterized by upregulation of CD69, shedding of CD16, or a combination of CD69+ and CD16-. These primed NK cells then contact second tumor cells, the cancer, and are configured to lyse and kill the second tumor cells.
priorityDate 2015-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA4ITL0
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP26891
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ7MVV7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ99ZP6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ49Z66
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ927U9
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID918500
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP10052
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5UP25
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0DB96
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP06478
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ898Y8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP18555
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0DB97
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB0K7G9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ38WJ3
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ6G7J1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP65230
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID9924867
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID116562
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ03181
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ814U0
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP65231
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9XSJ6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ1WM29
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP48092
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ7NVK0
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB8G6Y1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB0K1F4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ57NR0
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419512635
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID928935
http://rdf.ncbi.nlm.nih.gov/pubchem/anatomy/ANATOMYID13597
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID937033
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ82KI9
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID44999375
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ2P902
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP35396
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9PPP5
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID2656999
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ2PE47
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP27363
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID24271467
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID57133995
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP75070
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID1253269
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA6L1E7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ2PE78
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ71WN4
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID1209982
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC3LFK4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ29416
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5WB52
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ65RN9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ92N38
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP19114
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9QNF7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ6GEV6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB7JHF2
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID57203972
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8VVL0
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID61130153
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ4GZL1
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID3783741
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ05879
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB2RJJ6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ4L800
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ05880
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ65DU6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB0R5S5
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID403584
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB5YDB0
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ3Z0V3
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID56942394
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9RSY5
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5KUH1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ83A42
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0A3L9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP22649
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ6YRB1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0A3M0
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID22220432
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID1488261
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ2A3U3
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB5Y8S5
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5JGT7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB1L989
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP51747
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP04407
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP23331
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ72XC1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP23335
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9CHX5
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID1487533

Total number of triples: 404.