http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017048082-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d98762490c9bfd1551fefe55f49ea2c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1277 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-19 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 |
| filingDate | 2016-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9a6e3e683d259598d1231e5f97047d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a3e03c062f739439a81ba3728330447 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49737a7130759d0222a7bb8c9b8ae241 |
| publicationDate | 2017-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2017048082-A1 |
| titleOfInvention | Method for preparing liposomal freeze-dried powder using novel freeze-drying assisting agent and novel phospholipid-dissolving mixed solvent |
| abstract | The present invention relates to a liposome preparation method characterized in that a mixed solvent of ethyl acetate and n-hexane is used as a phospholipid-dissolving solvent used for liposome preparation, and to a liposomal freeze-dried powder preparation method characterized in that a container containing a liposome is placed into a container filled with at least one selected from among isopropyl alcohol, ethanol, and methanol, and then freeze-dried. The present invention uses a phospholipid by dissolving the phospholipid in a mixed solvent of ethyl acetate and n-hexane, and thus has the advantage of being usable in the food industry, unlike typical methods which use toxic chloroform. Moreover, in the present invention, since a container containing a prepared liposome is placed into a container filled with at least one selected from among isopropyl alcohol, ethanol, and methanol, and then freeze-dried, the time passing through the zone of maximum ice crystal formation is short. Thus, the present invention has the advantage in which a reduction in the stability of liposome, such as destruction of the liposome structure during the freeze-drying process and leakage of active material, may be prevented, and the advantage in which when restorating the powder, the powder almost completely returns to its original state. |
| priorityDate | 2015-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 67.