| abstract |
Provided are compounds shown in general formulae (I)-(IV) capable of being used as β-lactamase inhibitors, pharmaceutically acceptable salts thereof, esters thereof, and stereoisomers thereof, where R 1 , R 2 , M, and a ring A are as defined in the specification. Also provided are preparation methods for the compounds, and applications of the compounds. For example, the compounds can be used, as β-lactamase inhibitors, for treating and/or preventing bacterial infectious diseases, and resolving the problem of bacterial drug resistance caused by β-lactamases, particularly bacterial drug resistance diseases caused by B-class metal β-lactamase. |