| abstract |
A medicinal composition for preventing or treating an inflammatory respiratory disease, said medicinal composition comprising an RXR agonist represented by formula (1) or (2) as an active ingredient. The medicinal composition enables prevention or treatment of an inflammatory respiratory disease depending on a function mechanism different from conventional medicines. In formulae (1) and (2): D represents CMe 2 , N-methyl, N-ethyl or N-isopropyl; R 1 represents a methyl group, a hydroxy group, a methoxy group or an ethoxy group; R 2 represents H, a methyl group or an ethyl group; X represents N, CH or C-CF 3 ; Y and Z represent N or CH; R 3 represents an alkyl group, an alkenyl group, an alkynyl group or an aryl group; R 4 represents an alkyl group, an alkenyl group, an alkynyl group, an aryl group or an alkoxy group; W represents NR 5 or CR 5 n 2 ; R 5 represents hydrogen, an alkyl group, an alkenyl group, an alkynyl group or an aryl group; X 1 and Y 1 represent CH or N; X 2 and Y 2 represent CH, CR 6 or N; R 6 represents an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, a halogen, a nitro group or an amino group; and Z 1 represents a carboxyl group, a carboxylic acid ester or hydroxamic acid that is boded either directly or via a linking group. |