| abstract |
Disclosed are 2-methylene analogs of vitamin D 3 and related compounds, their biological activities, and various pharmaceutical uses for these analogs. Particularly disclosed are 1α-hydroxy-2-methylene-vitamin D 3 , (20 S )-1α-hydroxy-2-methylene- vitamin D 3 , and (5 E )- 1α,25-dihydroxy-2-methylene- vitamin D 3 , their biological activities, and various pharmaceutical uses for these compounds including methods of treating and/or preventing bone diseases and disorders. |