http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017022650-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_96fb15dad93b6948b91eca572da44bae |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0016 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate | 2016-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_793421766ffbaf784d249dbd45f15983 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c42745e092081f196e994e724b273518 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6165bf714ff85e737cf2181cbf27f4b |
| publicationDate | 2017-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2017022650-A1 |
| titleOfInvention | MODIFIED siRNA, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME |
| abstract | Provided are: modified siRNA for inhibiting the expression of RecQL1 helicase gene; a RecQL1 gene expression inhibitor and a cell death inducer, each of which comprises the modified siRNA; and a pharmaceutical composition for treating cancer, which contains the modified siRNA. Double-stranded modified siRNA which contains a sense strand comprising the nucleotide sequence represented by SEQ ID NO: 1 and an antisense strand comprising the nucleotide sequence represented by SEQ ID NO: 2 and which can target RecQL1 helicase gene, wherein the sense strand contains 2'-substituted nucleotides respectively located at position-2, position-3, position-4 and position-13 in the nucleotide sequence represented by SEQ ID NO: 1, the sense strand additionally contains 2'-substituted nucleotides respectively located at at least one position selected from the group consisting of position-12, position-14, position-17, position-18 and position-19 in the nucleotide sequence represented by SEQ ID NO: 1, and the position-2' in each of the 2'-substituted nucleotides represents -R 1 , -OR 1 , -R 2 OR 1 , -OR 2 OR 1 or -R 3 OR 2 OR 1 in which wherein R 1 represents a C 1-4 alkyl group and R 2 and R 3 independently represent a C 1-3 alkylene group; a RecQL1 gene expression inhibitor and a cell death inducer, each of which comprises the modified siRNA; and a pharmaceutical composition for treating cancer, which contains the modified siRNA. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023098908-A1 |
| priorityDate | 2015-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 82.