| abstract |
The present disclosure discloses compositions comprising codon-optimized nucleotide sequences, in particular mRNAs, that encode antibodies and functional fragments thereof (e.g., antigen-binding fragments or Fc fragments that can be used in fusion proteins). These optimized nucleic acid sequences can be used to expressing therapeutic antibodies in vivo. Also provided are methods of manufacturing the disclosed codon-optimized nucleotide sequences, methods of generating therapeutic antibodies in a subject in need thereof by administering a polynucleotide comprising a codon-optimized nucleotide sequence, and methods for treating and/preventing a disease or condition in a subject using the disclosed compositions and methods. |