| abstract |
In one aspect, a vector for expressing human APOBEC3B generally includes a first region having homology to a mouse gene, a /ox-STOP- lox (LSL) cassette, and a human APOBEC3B gene. The LSL cassette includes two loxP sites, a first promoter, a drug resistance gene, and a first poly-A region. In another aspect, a vector for expressing human APOBEC3B generally includes a Rosa26 promoter, a human APOBEC3B gene, and a polyadenylation region. In another aspect, a transgenic mouse includes a vector that includes a human APOBEC3B gene so that the mouse expresses the human APOBEC3B gene. |