| abstract |
The present invention concerns 2-amino-pyridin-3-yl carboxamide and 3-amino-pyrazin-2-yl carboxamide derivatives of formula (I): (I) or a pharmaceutically acceptable salt thereof, wherein: • A is N or C-H, • Y is 0, S or one of the following groups : sulfoxide (-S(O)-), sulfone (- S(0) 2 -) or N (R 3 ) with R 3 being H, or an optionally substituted alkyl, acyl, alkenyl, alkynyl, cycloalkyl, aralkyl, aryl or heteroaryl, • R 1 is H or an optionally substituted alkyl, acyl, alkenyl, alkynyl, cycloalkyl, aralkyl, aryl or heteroaryl, or when Y is NR 3 , R 1 and R 3 are together included into an optionally substituted 4 to 7-membered heterocycle or 8 to 10-membered heterobicycle, and • R 2 is any of the optionally substituted following groups: alkyl, acyl, alkenyl, alkynyl, cycloalkyl, aralkyl, aryl, heteroaryl-alkyl or heteroaryl; for use as polo-like kinase 2 inhibitors for the treatment of cancer; as well as pharmaceutical compositions containing such a compound and processes to prepare such a compound. |