| abstract |
A crystal of a compound represented by general formula (I) (wherein R 1 represents a hydrogen atom or a hydroxyl group, and R represents a 2-(trifluoromethyl)pyrimidin-5-yl group or a 5-(trifluoromethyl)pyrazin-2-yl group) or a pharmacologically acceptable salt thereof, which has excellent LCAT activating activity and is useful as an active ingredient for a therapeutic agent or prophylactic agent for arteriosclerosis, arteriosclerotic heart diseases, coronary heart diseases (including heart failure, myocardial infarction, angina pectoris, cardiac ischemia, cardiovascular disorders and angioplasty restenosis), cerebrovascular diseases (including cerebral apoplexy and cerebral infarction), peripheral vascular diseases (including diabetic vascular complications), dyslipidemia, low-HDL cholesterolemia or kidney diseases, especially as an active ingredient for an anti-arteriosclerotic agent. |