| abstract |
The present invention relates to a novel and improved process for the preparation of the compound 2-{4-[2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)-pyridin-4-yl]-phenoxy}-ethyl-L-alanyl-L-alaninate monohydrochloride of formula (I), new precursors for their preparation, as well as to the production and use of the crystalline modification I of 2-{4-[2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl]phenoxy}ethyl-L-alanyl-L-alaninate monohydrochloride of formula (I). |