| abstract |
The present invention relates to novel 5-substituted-7-[4-(2-pyridyl) phenylmethylamino]-3-isopropylpyrazolo[4,3-d]pyrimidines of formula I which are potent inhibitors of protein kinases, especially cyclin- dependerit kinases such as CDK2 and CDK5, and display antileukemic, pro-apoptotic, antiangiogenic and anticancer activities. The invention also relates to processes for their preparation, to pharmaceutical compositions comprising them and to their use as medicaments, particularly in the treatment of disorders involving cell proliferation, apoptosis, angiogenesis and inflammation, such as leukemia and metastatic solid cancer. |