| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e071d18fea054bf8d1420d483e78ed1 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-365
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04 |
| filingDate |
2016-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8738403a79dbe58e6cae767ece0bd9dc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86745584d5e9a918a0b854db0b7a4a89
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21576a4487ae1da5d45eccf70b5b6e0d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7941499387af3757e4d369c3b3bf678c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ca8dcb7276051b3ee995359b33dfe75 |
| publicationDate |
2017-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2016176560-A8 |
| titleOfInvention |
Chromium-mediated coupling and application to the synthesis of halichondrins |
| abstract |
The present invention provides unified synthesis of the CI -CI 9 building blocks of halichondrins and analogs theoreof using selective coupling of poly-halogenated nucleophiles in chromium-mediated coupling reactions. The present invention also provides a practical and efficient synthesis of C20-C38 building blocks of halichondrins and analogs thereof. Also provided herein are general methods of selective activation and coupling of poly-halogenated analogs with an aldehyde. The provided coupling reactions are selective for halo-enone and halo-acetylenic ketal over vinyl halide and halide attached to a sp hydridized carbon. The provided efficient selective coupling reactions can allow easy access to the CI -CI 9 building blocks and C20-C38 building blocks of halichondrins and analogs thereof with limited or no purification or separation of the intermediates. |
| priorityDate |
2015-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |