| abstract |
Provided in the present invention are macrolide derivatives and a use thereof. The macrolide derivative has the following general structure formula (I) wherein R 1 is selected from hydrogen, hydroxy, halogen, C 1 -C 6 alkyl, C 1 -C 4 alkoxy, C 1 -C 6 alkenyl, (CH 2 ) m (a C 6 -C 10 membered aryl), (CH 2 )m(C 5 -C 10 membered heteroaryl) or C 2 -C 10 alkynyl group; R 2 , R 3 are selected from hydrogen, hydroxy, halogen, C 1 -C 6 alkyl, C 1 -C 6 alkenyl group, (CH 2 )m(C 6 -C 10 membered aryl), (CH 2 )m(C 5 -C 10 membered heteroaryl), C 2 -C 10 alkynyl, C 1 -C 4 alkoxy and a pyranose group, wherein the pyranose group is unsubstituted or substituted with one or more of the following groups: hydrogen, halogen, C 1 -C 6 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 alkanoyl or C 1 -C 4 alkanoyloxy; each m is independently being an integer of 0-4. The compounds can be used to prepare drugs which have a function of promoting digestive power, have a low antibiotic activity, and have few side effects. |