| abstract |
A compound which is an isoxazolyl imidazopyridine of formula (I): wherein: R 0 and R, which are the same or different, are each H or C alkyl; R 9' and R 9" , which are the same or different, are each H or F; X is -(alk) n -, -alk-C(=O)-NR-, -alk-NR-C(=O)- or -alk-C(=O)-; R 1 is selected from -S(=O) 2 R' and a 4- to 7-membered heterocyclic group which is unsubstituted or substituted; R 2 and R 2' , which are the same or different, are each H or C 1-6 alkyl; or R 2 and R 2' form, together with the C atom to which they are attached, a C 3-6 cycloalkyl group; R 3 and R 3' , which are the same or different, are each H, C 1-6 alkyl, OH or F; R 4 is phenyl or a 5- to 12-membered N-containing heteroaryl group and is unsubstituted or substituted; alk is C 1-6 alkylene; R' is C 1-6 alkyl; and n is 0 or 1; or a pharmaceutically acceptable salt thereof. The compound has activity in modulating the activity of p300 and/or CBP and is used to treat cancer. |