http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016165678-A1

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filingDate 2016-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2016-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2016165678-A1
titleOfInvention Process for particle size reduction of aclidinium bromide
abstract The present solution relates to a process for manufacturing aclidinium bromide particles for use in a pharmaceutical formulation, wherein said process comprises micronization of aclidinium bromide having a particle size higher than 30 Mm and conditioning of the micronized aclidinium bromide for obtaining aclidinium bromide having a particle size less than 10 pm and an amorphous part less than 3 wt%. A further solution relates to a process for manufacturing a pharmaceutical formulation, wherein aclidinium bromide is mixed with at least one pharmaceutically acceptable excipient.
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