| abstract |
The present invention provides a method for producing glycoside compounds represented by general formula (I) or salts thereof, said method comprising: a step (step 0) in which a thioether compound represented by general formula (103) and an alcohol compound represented by general formula (105) are made to undergo a coupling reaction in the presence of a halogenating agent, a desiccant, and a Lewis acid, and a thioether compound represented by general formula (104) is obtained by distilling the reaction product in the presence of at least one additive selected from a sulfur-containing anti-oxidant and a maleimide group-containing compound; and a step (step 1) in which, in the presence of the halogenating agent, desiccant, and Lewis acid, a glycoside compound represented by general formula (Ia) and the thioether compound represented by general formula (104) are made to undergo a coupling reaction to obtain a glycoside compound represented by general formula (Ib). This method enables phosphoramidites appropriate for the production (synthesis) of nucleic acids to be more efficiently produced with high purity. (Each compound is as defined in the specification.) |