| abstract |
The present disclosure relates to indole analogs of Formula I as 5-oxo-ETE receptor antagonists wherein R 1 , R 2 , R a , R b , L, X, m and n are as defined herein. Methods for the preparation of compounds of Formula I, pharmaceutical compositions comprising such compounds and their use for the treatment of conditions related to 5-oxo-ETE receptors are also disclosed. The compounds are useful for the treatment or prophylaxis of a disease or condition selected from asthma, allergic rhinitis, chronic obstructive pulmonary disorder, atopic dermatitis, psoriasis and acne. |