| abstract |
The present invention relates to a compound of the general formula (III) or a salt, solvate or prodrug thereof, as well as medical uses involving them, wherein (III) A 1 is selected from the group consisting of N and C-R 8 ; A 2 is selected from the group consisting of N and C-R 3 ; A 3 is selected from the group consisting of N and C-R 9 ; A 4 and A 5 and A 6 are independently selected from the group consisting of N and C-R 1 ; R 1 is selected from the group consisting of hydrogen, (C 1 -C 3 )alkyl, halogen, (C 1 -C 3 )alkoxy and (C 1 -C 3 )haloalkyl; R 2 is selected from the group consisting of hydrogen, halogen and (C 1 -C 3 )alkyl; R 3 is selected from the group consisting of hydrogen, (C 1 -C 3 )alkyl, NR 4 R 5 , (C 1 -C 3 )alkyl- NR 4 R 5 and cyano; wherein R 4 and R 5 are independently selected from the group consisting of hydrogen, (C 3 - C 5 )cycloalkyl, (C 3 -C 5 )heterocycloalkyl, (C 1 -C 3 )alkyl, or R 4 and R 5 together with the nitrogen atom to which they are attached form a 5- to 7-membered heterocyclic ring optionally comprising in addition to the aforementioned nitrogen atom a further heteroatom group selected from the group consisting of O and NR 6 , wherein R 6 is selected from the group consisting of hydrogen, methyl, acetyl and formyl; Y is selected from the group consisting of O and S; R 7 is selected from the group consisting of hydrogen, and (C 1 -C 3 )alkyl; R 8 is selected from the group consisting of (C 1 -C 4 )alkyl, (C 3 -C 5 )cycloalkyl, and (C 3 - C 5 )heterocycloalkyl; R 9 is selected from the group consisting of hydrogen, (C 1 -C 3 )alkyl, (C 1 -C 3 )alkoxy, and methods for producing such compounds. |