| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ad1ad79b065910fb3c349b44b3d38bec |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4745 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-535 |
| filingDate |
2016-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4714e820cef65bd48e5877b8b9c3c6ec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4de54fe7940e73d5387c763a26903d94
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b780090d41e8fca7a8491db9d5fd8eac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08f88b73e572c4aadf263bb5a7179071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a85631e25bdb6a51e070c5eb350160f3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_863b45fd097af5595e54d7e0dfde1fba |
| publicationDate |
2016-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2016141296-A1 |
| titleOfInvention |
Tricyclic kinase inhibitors of melk and methods of use |
| abstract |
Provided herein are tricyclic small molecule inhibitors of maternal embryonic leucine zipper kinase (MELK). The compounds are useful for treating cancer and other conditions or diseases associated with aberrant MELK expression. Also provided herein are pharmaceutical compositions comprising a tricyclic compound of the invention and a pharmaceutically acceptable carrier. The invention also provides methods of treating cancers associated with over-expression of MELK. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022096361-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3992191-A1 |
| priorityDate |
2015-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |