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filingDate 2016-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5066f16c7d9812aee6fd7a38980ece87
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publicationDate 2016-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2016134164-A1
titleOfInvention Methods of enhancing cerenkov luminescence using nanoparticles, and compositions related thereto
abstract Cerenkov luminescence occurs when a charged particle travels through a medium faster than a speed of light in that medium. The luminescence generated depends on the refractive index of the material and the energy of the particle traveling through the dielectric medium. Biomedical applications of Cerenkov luminescence currently utilize radionuclides producing Cerenkov light through interactions with tissue, which has a refractive index range of 1.36-1.41. The present disclosure describes the enhancement of Cerenkov luminescence through coupling various radionuclides to different biocompatible nanoparticles that have refractive indices greater than tissue.
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