| abstract |
A nanopore sensor is provided, including a nanopore disposed in a support structure. A fluidic passage is disposed between a firsifiuidic reservoir and the nanopore to fluidically connect the first fiuidie reservoir to the nanopore through the fluidic passage. The fluidic passage has a passage length that is greater than the passage width, A second fluidic reservoir is fluidically connected to the nanopore, with the nanopore providing fluidic communication between the fluidic passage the second reservoir. Electrodes are connected to impose an electrical potential difference across the nanopore. At least one electrical transduction element is disposed in the nanopore sensor with a connection to measure the electrical potential that is local to the fiuidie passage. |