| abstract |
Bone-mimetic microstructures are formed within the paper scaffolds. Centimeter scale paper origami scaffolds are seeded with osteoblasts and cultured to induce formation of mineral deposits. The paper-based platform is a promising system to study mechanisms of biomineralization, repair mineralized tissues, understand healing and regeneration of bone, develop therapeutic approaches when mineralization is impaired, and understand the fundamental processes in biomineralization events. |