| abstract |
These compounds are of formula (la), (lb), (Ic), or are stereoisomers thereof, wherein: R 1 is hydrogen, (C 1 -C 20 )alkyl; (C 3 -C 20 )alkenyl; (C 3 -C 20 )alkynyl; (C 1 - C 6 )alkyl-O-; (C 3 -C 20 )cycloalkyl; (C 1 -C 20 )haloalkyl; (C 6 -C 20 )aryl optionally substituted; (C 6 -C 20 )heteroaryl optionally substituted;; R 2 and R 2' are hydrogen; (C 1 -C 20 )alkyl; (C 1 -C 6 )alkyl-O-; (C 1 -C 6 )haloalkyl; halogen;cyano; and nitro; to Z 1 to Z 4 are diradicals of formula (III) wherein A 1 and A 2 are -O- or -NR 3 -, wherein R 3 is selected from the group consisting of hydrogen and (C 1 - C 20 )alkyl; and G is (C 1 -C 6 )alkyl;;-P(=S)R 5 -; -P(=O)R 4 ; -P(=O)(OR 4 )-; - P(=O)(NR 6 R 7 )-; -S(=O) 2 -; -S(=O)-; or -C(=O)-; and Y 1 to Y 4 are (C 1 -C 8 )alkyl; (C 3 -C 7 )cycloalkyl; (C 6 -C 20 )aryl optionally substituted; or (C 6 -C 20 )heteroaryl optionally substituted; and FG 1 and FG 2 are H, OH, or NHR 8 . These compounds are useful as ionophores for creatinine quantification. |