| abstract |
A method of performing isolation and purification of bedaquiline (la) from a mixture of stereoisomers of 6-bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-(l-naphthyl)-l- phenyl-butan-2-ol identified as I-rac, being a mixture of the stereoisomers of formulae la, lb, and II-rac, being a mixture of the stereoisomers of formulae Ila, lib, with any ratio of individual constituents of the mixture, wherein said mixture is dissolved together with derivatives of 1,3 -propanediol hydrogen phosphate of formula IV, wherein R 1 , R 2 , and R 3 independently stand for hydrogen, a halogen, C 1 -C 6 alkyl, aryl, naphthyl, phenyl and preferably a halogenated phenyl or phenyl substituted in any way, and the resulting salt is crystallized. |