| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eb9c6b40161bafe7bd55f0b4defcea04 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2503-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2513-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0693
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5082
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M23-16 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M3-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-09 |
| filingDate |
2016-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dab501a1aa1c2660b18c637b30e34c80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9055bfed70a17114800c51b11d88475a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf8f98ce02f9be209e9228e39aac2f19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88d2061df9c277f1a8e5f63ed25f47f7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_754024ee1f9b1e00861f4d3062319d41 |
| publicationDate |
2016-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2016112172-A1 |
| titleOfInvention |
Microfluidic cell culture of patient-derived tumor cell spheroids |
| abstract |
Provided herein are methods for culturing patient-derived tumor cell spheroids in a three-dimensional microfluidic device. The method comprises mincing primary tumor sample in a medium supplemented with serum; treating the minced primary tumor sample with a composition comprising an enzyme; collecting tumor spheroids having a diameter of 10 μηι to 500 μιη from the enzyme treated sample; suspending the tumor spheroids in biocompatible gel; and culturing the tumor spheroids in a three dimensional microfluidic device. Methods for identifying an agent for treating cancer and microfluidic devices that allow for the simultaneous exposure of the cultured patient-derived primary tumor cell spheroids to a treatment of choice and to control treatment are also provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018231993-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3600425-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10472599-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109321528-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11737452-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11098369-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2023003716-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102152492-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019035618-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7284095-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11572590-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018044940-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20190018306-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11555180-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019226120-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018183839-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102579906-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110505881-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2020515260-A |
| priorityDate |
2015-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |