| abstract |
Provided are methods of treating brain ischemia or hypoxia by using an inhibitor of cysteine-glutamate transporter. The inhibitor includes sorafenib and a derivative thereof, regorafenib, erastin and sulfasalazine. The inhibitor can effectively decrease a concentration of extracellular glutamate, so that excitotoxicity to nervous system and a cortical infarct volume in brains may be reduced. |