| abstract |
This novel bisphosphonic acid derivative, which has a heterocyclic group containing a heterocyclic group-substituted amino group or a nitrogen atom, the acid moiety being esterified by a POM group or a n-butanoyloxymethyl (BuOM) group, and which is represented by the following general formula (1): Y-Cy-(NH) m -(CH 2 ) n -C(X) (PO(OR 1 ) (OR 2 )) 2 (1) (where the symbols are defined in the description) exhibits excellent direct and indirect cytopathic effect against tumor cells and virus-infected cells. |