| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_70ce66298537a102941cd1db7054f1f7 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-727
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-45
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-155 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5058
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0606
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0623
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0662 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N63-00 |
| filingDate |
2015-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e97a087a87e0947485bc1fce2d490d6c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f48257203a3cf4c86360053e71d0e338 |
| publicationDate |
2016-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2016086052-A1 |
| titleOfInvention |
Derivation of nueral crest stem cells and uses thereof |
| abstract |
The present invention is based in part the discovery of methods for the generation of neural crest stem cells (NCSCs) from human pluripotent stem cells (hPSCs). Specifically, the present invention discloses methods for the use of a combination of rho-associated protein kinase (ROCK) inhibitors, glycogen synthase kinase 3 (GSK-3) inhibitors, activing receptor like kinase (ALK) receptor inhibitors and bone morphogenic protein (BMP) receptor inhibitors to derive NCSCs from hPSCs. The present invention also discloses methods to treat neurocristopathic diseases and disorders using NCSCs derived from hPSCs. |
| priorityDate |
2014-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |