| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a325d435d18ee4ef060aab2b1dca2706
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1842edd53fa77adc4c343ff2c83dc3b7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_29f3d5c0128ac5df77ea41dd68801831
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7e7409b772ae5693016868a0d94a7fd9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_193cfd5a9166abd5e409d5eecac44e6a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d53dfac2d1e61a7362746c85f1101c2b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2300-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-573
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5685
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0014
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-192
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-365
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-062
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61Q19-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61Q19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-107 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-192
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5685
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00 |
| filingDate |
2015-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33e5d976bc6244a434830daf189dedf5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e34f9530f79627c13cae8b6f6ad15c85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c21ac9eb59895f804851fb5a593b98a6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93e999bbda469b9d4be1b6e2ad0aedc6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c43965db0eaa16e921c65f92b64f5df3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d287928412df61df829265f35b5f87cd |
| publicationDate |
2016-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2016083325-A1 |
| titleOfInvention |
Treatment of skin atrophy with a combination of triiodothyroacetic acid (triac) and dehydroepiandrosterone (dhea) |
| abstract |
The aim of the present study was to investigate the effect of a combination of triiodothyroacetic acid (TRIAC) and dehydroepiandrosterone (DHEA) compared with TRIAC, DHEA or placebo alone on corticosteroid induced effect on collagen synthesis in humans. Six healthy male human volunteers aged 40-65 participated. Four areas of abdominal skin were pre-treated for 3 weeks with betamethasone valerate cream. The same areas were then treated with one of the following alternatives in the same cream vehicle: TRIAC, DHEA, TRIAC+DHEA and placebo for 2 weeks. Then suction blisters were raised in each of these areas with a vacuum pump. The blister fluid from each area was collected and frozen until analysis. Analysis of amino terminal propeptide of human type I procollagen (PINP) in suction blister fluid was performed using a commercially available immunoassay (Orion Diagnostics) kit. This study has for the first time shown that a combination of TRIAC and DHEA could effectively stimulate collagen synthesis in skin pretreated with betamethasone valerate demonstrated by an increase in PINP, and that the combination was more effective than TRIAC or DHEA alone. This combination could be used to effectively treat skin atrophy in corticosteroid induced skin atrophy. It could also be used to treat skin atrophy due to other circumstances such as e. g. sun damaged skin and skin atrophy due to high age. Another interesting application would be to combine TRIAC and DHEA with a potent corticosteroid in order to prevent corticosteroid induced skin atrophy. If this combination still is effective in the treatment of eczema and psoriasis and without the risk of skin atrophy this combination will be a major breakthrough for the use of potent topical corticosteroids. |
| priorityDate |
2014-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |